About
The 'Response to Injury Hypothesis' proposed by Dr. Russell Ross in 1976 offers a transformative perspective on how cardiovascular disease develops. At its core, the hypothesis explains that the initial injury to arterial walls often stems from elevated cholesterol levels and the subsequent oxidation that plagues these vital structures. In response to this injury, the body activates an inflammatory reaction which aims to eliminate cholesterol deposits from the artery wall, highlighting a natural healing mechanism.
Highlights
However, this response can become dysregulated, leading to further complications. As inflammation persists unchecked, it can exacerbate the deposition of cholesterol and create vulnerable plaques within the arteries. These plaques, when ruptured, pose significant risks, notably heart attacks and strokes, underscoring the critical role of inflammation in cardiovascular health. Dr. Ross’s work is foundational for understanding the intricate relationship between cholesterol, arterial health, and the inflammatory processes that can propel cardiovascular disease. This hypothesis not only brings forth new avenues for research but also emphasizes the importance of monitoring and managing cholesterol levels to reduce cardiovascular risks.